The increasing diabetic population, as well as the prevalence of high-fat diet-induced pre-diabetic conditions, have made it imperative to develop more effective and safe long-term prevention and treatment strategies. In recent years, both the physical method static magnetic field (SMF), and the endogenous hormone fibroblast growth factor 21 (FGF21) have shown promising treatment efficacy in type 2 diabetic animals. In this study, we further examined the effects of SMFs and FGF21SS (a thermal-stable FGF21 analog) on the other two types of diabetes, pre-diabetes and type 1 diabetes (T1D) in mice. Our results show that continuous SMF exposure alone can reduce hyperglycemia by 28.5% (p SS, and the fasting blood glucose reduction was increased from 29.3% in FGF21SS groups to 50.3% in the combinational groups for T1D mice (p SS groups to 19.2% in the combinational groups for pre-diabetic mice (p < 0.05). Tissue examination shows that the combination of SMF and FGF21SS can effectively reduce oxidative stress in the mouse liver and pancreatic islets, as well as lipid deposition in the liver, which contributes to alleviating diabetes. Therefore, our study presents an effective and safe strategy that can be potentially applied in diabetes management in the future.
Cheng et al. (Sun,) studied this question.