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This research evaluates the interaction between apalutamide and cyclosporine, particularly focusing on the CYP3A4 induction.

February 28, 20260 citationsOpen Access

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Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide.

YMYoshihisa Mimura TSTakaomi Sanda RURei Unno

Key Points

This research evaluates the interaction between apalutamide and cyclosporine, particularly focusing on the CYP3A4 induction.
Evaluation of drug interactions in a clinical case report.
Monitoring of CYP3A4 activity in response to apalutamide administration.
Observational analysis of patient responses to combined medication.
Apalutamide induced CYP3A4 via the pregnane X receptor pathway.
A sustained drug-drug interaction was observed with cyclosporine.
Careful monitoring is recommended for patients using CYP3A4 substrates.

Abstract

Apa induced CYP3A4 via the PXR pathway, leading to a sustained DDI with CsA. Careful monitoring is necessary when Apa is coadministered with CYP3A4 substrates.

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Cite This Study

Mimura et al. (Thu,) studied this question.

synapsesocial.com/papers/69a286b80a974eb0d3c01dc6 https://doi.org/https://doi.org/10.1155/crom/3539500

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