What question did this study set out to answer?

This research investigates the therapeutic potential of targeting YAP1 signaling in cancer.

February 28, 20262 citations

YAP1 signalling and cancer: molecular pathways reveal novel targeting opportunities.

JWJialin WuChinese University of Hong Kong BCBonan ChenHubei University of Medicine FXFuda Xie

Key Points

This research investigates the therapeutic potential of targeting YAP1 signaling in cancer.
Discussed the dual roles of YAP1 in tissue repair and stemness.
Evaluated combinations of YAP1 inhibitors with other agents.
Emphasized the need for biomarkers to assess YAP1 activation.
Pairing YAP1/TEAD inhibitors with immune checkpoint blockers may improve clinical outcomes.
Identifying robust biomarkers of YAP1 activation is crucial for treatment development.
Need for strategies that enhance antitumor effects while reducing systemic toxicity.

Abstract

Therapeutically inhibiting YAP1/TAZ signaling holds substantial promise. Yet the dual physiological roles of YAP1 in tissue repair and stemness underscore the need for highly selective and temporally controlled interventions. Rational combinations, such as pairing YAP1/TEAD inhibitors with immune checkpoint blockade, anti-fibrotic agents, may enhance clinical benefit. Future work should prioritize the development of robust biomarkers of YAP1 activation, deeper mapping of TEAD-dependent versus TEAD-independent functions, and optimization of strategies that maximize antitumor efficacy while limiting systemic toxicity.

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