Novel ERAS-based cardiac rehabilitation training reduced adverse cardiac events to 6.52% compared to 23.91% with routine rehab in AMI patients post-PCI after 3 months.
RCT (n=92)
Random number table method
No
Does novel cardiac rehabilitation training based on ERAS improve cardiac function and exercise endurance in patients with acute myocardial infarction after PCI?
ERAS-based cardiac rehabilitation significantly improves cardiac function, exercise capacity, and reduces adverse events in AMI patients post-PCI.
Effect estimate: P < 0.05 for difference in adverse cardiac event rates (experimental group 6.52% vs control 23.91%)
Absolute Event Rate: 6.52% vs 23.91%
p-value: p=<0.05
ObjectiveTo investigate the effect of novel cardiac rehabilitation training on cardiac function in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) based on enhanced recovery after surgery (ERAS).MethodsA total of 92 AMI patients admitted to the cardiology department of Dongying District People's Hospital from May 2020 to May 2023 were selected and randomly divided into control group and experimental group using a random number table method, with 46 patients in each group. Both groups received standardized symptomatic treatment and PCI surgery after admission. The control group received routine cardiac rehabilitation training in addition to the standardized treatment. On the basis of standardized treatment and routine cardiac rehabilitation training, the experimental group was given a new type of cardiac rehabilitation training based on ERAS. Peak power (PP), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) were measured using a color echocardiography diagnostic instrument before training, after one month of training, and after three months of training; Cardiopulmonary Exercise Testing were used to assess exercise endurance, including exercise duration (ED), peak oxygen uptake (VO2), and anaerobic threshold (AT); N-terminal pro-brain natriuretic peptide (NT-proBNP) was measured using the Roche Cobas e411 chemiluminescence analyzer; superoxide dismutase (SOD) activity was measured using the xanthine oxidase method; malondialdehyde (MDA) expression level was measured using the thiobarbituric acid colorimetric method; total antioxidant capacity (T-AOC) was measured using the phenanthrene colorimetric method; expression levels of interleukin-18 (IL-18), nucleotide-binding oligomerization NOD-like receptor protein 3 (NLRP3), and interleukin-1β (IL-1β) were measured using the enzyme-linked immunosorbent assay, and expression level of nuclear factor kappa B (NF-κB) was measured using the enzyme-linked immunosorbent assay. Cardiopulmonary function was evaluated with the 6-Minute Walk Test (6MWT). The Myocardial Infarction Dimensional Assessment Scale (MIDAS) was used to evaluate the patients' quality of life.ResultsCompared with those before training, PP and LVEF increased in both groups after one month and three months of training (PPPPPP2 peak and AT values after 1 month and 3 months of training (PP2 peak and AT values (PP2 peak and AT value after one month and three months of training (PPPPPPPPPPPPPPPConclusionThe novel ERAS-based cardiac rehabilitation training can regulate heart failure markers, antioxidant capacity, and inflammation levels in AMI patients after PCI, which helps improve cardiac function, enhance exercise endurance, and reduce the risk of adverse cardiac events.
CHENG et al. (2026) conducted an RCT in Patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) with Killip class I-II heart function, admitted within 10 hours of onset (n=92). Novel cardiac rehabilitation training based on enhanced recovery after surgery (ERAS) vs. Routine cardiac rehabilitation training plus standardized treatment was evaluated on Composite cardiac function and exercise endurance parameters and incidence of adverse cardiac events during 3 months of training (P < 0.05 for difference in adverse cardiac event rates (experimental group 6.52% vs control 23.91%), p=<0.05). Novel ERAS-based cardiac rehabilitation training reduced adverse cardiac events to 6.52% compared to 23.91% with routine rehab in AMI patients post-PCI after 3 months.