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March 1, 2026RSC Medicinal Chemistry0 citations

Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

WFWanting FuKWKeren WangHCHongsong Chen

Key Points

  • This research aims to develop and evaluate new compounds that can inhibit both AChE and MAO-B enzymes to treat Alzheimer's disease effectively.
  • Synthesis of 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives
  • Biological evaluation of synthesized compounds as dual inhibitors
  • Assessment of efficacy against AChE and MAO-B enzymes
  • Several derivatives exhibited significant inhibition of AChE and MAO-B.
  • New compounds showed potential to improve therapeutic outcomes for Alzheimer’s disease.
  • Results indicate a multi-target approach may be effective in AD treatment.

Abstract

Alzheimer’s disease (AD) is an irreversible degenerative disorder of the brain, and there is no effective drug for it to date. Given its complex pathogenesis, the multi-target-directed ligands (MTDLs) strategy...

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Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/69a3d800ec16d51705d2e735https://doi.org/10.1039/d5md01138h
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