Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

Wanting Fu; Keren Wang; Hongsong Chen; Tao Liu; Xiaojuan Liu; Qishun Jin; Zhenghuai Tan; Wu Dong; Wenmin Liu; Zhi-Pei Sang

doi:10.1039/d5md01138h

January 1, 2026RSC Medicinal Chemistry

Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

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Key Points

This research aims to develop and evaluate new compounds that can inhibit both AChE and MAO-B enzymes to treat Alzheimer's disease effectively.
Synthesis of 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives
Biological evaluation of synthesized compounds as dual inhibitors
Assessment of efficacy against AChE and MAO-B enzymes
Several derivatives exhibited significant inhibition of AChE and MAO-B.
New compounds showed potential to improve therapeutic outcomes for Alzheimer’s disease.
Results indicate a multi-target approach may be effective in AD treatment.

Implication

Research demonstrates new dual inhibitors improve treatment options in Alzheimer's disease, suggesting potential progress in drug development.

Abstract

Alzheimer’s disease (AD) is an irreversible degenerative disorder of the brain, and there is no effective drug for it to date. Given its complex pathogenesis, the multi-target-directed ligands (MTDLs) strategy...

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Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/69a3d800ec16d51705d2e735 https://doi.org/10.1039/d5md01138h

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Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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