Design, synthesis, and biological evaluation of cycloarylchalcone derivatives as microtubule inhibitors targeting breast cancer cells.

Key Points

• The central aim is to assess the anticancer properties of cycloarylchalcone derivatives against breast cancer cells.
• Synthesis of cycloarylchalcone derivatives
• Biological evaluation of anticancer activity
• Targeting microtubule dynamics in breast cancer cells
• Cycloarylchalcone derivatives show significant anticancer activity
• Promising leads for further preclinical studies
• Inhibition of microtubule function observed in treated cells