Impact of Thiazides and Fluoropyrimidines Interaction on Myelotoxicity and Other Adverse Events in Real-World Practice: A Retrospective Cohort Study.

Key Points

• To evaluate how thiazides and fluoropyrimidines interact and affect myelotoxicity and other adverse events in real-world settings.
• Conducted a retrospective cohort analysis
• Utilized data from Spanish Clinical Studies Registry and EMA-RWD Catalogs
• Assessed myelotoxicity and adverse events in patients
• Found significant impacts of thiazide and fluoropyrimidine interactions on myelotoxicity
• Identified various adverse events related to this drug interaction
• Results indicate the necessity for careful monitoring of patients receiving these treatments.