A simulation study to assess the influence of population pharmacokinetic model selection on Bayesian forecasting of vancomycin exposure in preterm neonates.

Key Points

• This study explores how selecting different pharmacokinetic models affects the forecasting of vancomycin exposure in preterm neonates.
• Conducted simulation study to assess different population pharmacokinetic models.
• Evaluated the impact on vancomycin AUC24 values and probability of target attainment (PTA).
• Analyzed correlations between model characteristics and dosing outcomes.
• Different models led to variations in AUC24 values for vancomycin.
• Observed significant differences in PTA across models.
• Findings suggest certain model characteristics enhance target attainment.