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March 2, 20260 citations

Association between serum α-Klotho levels and severity of periodontitis in a representative U.S. population.

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HSHamoun SabriUniversity of MichiganSBSahar BaniameriUniversity of MichiganPKPranav KatariaUConn Health

Key Points

  • This research aims to explore the relationship between serum α-Klotho levels and the severity of periodontitis.
  • Analyzed serum α-Klotho levels in a representative U.S. population
  • Assessed periodontitis severity
  • Evaluated predictors such as age, smoking, and comorbidities
  • No significant association between serum α-Klotho and periodontitis severity was found
  • Age, smoking, and comorbidities were identified as key predictors
  • Further research is suggested to determine if α-Klotho is a useful biomarker for periodontal conditions

Abstract

No significant association was found between serum α-Klotho levels and periodontitis severity. Age, smoking, and comorbidities were key predictors, highlighting the multifactorial nature of periodontitis. Further longitudinal and mechanistic studies are needed to clarify whether α-Klotho has a value as a biomarker of periodontal inflammation or disease progression.

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Cite This Study

Sabri et al. (2026) studied this question.

synapsesocial.com/papers/69a52df3f1e85e5c73bf13bchttps://doi.org/10.1002/jper.70080
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