What question did this study set out to answer?

The research aims to investigate the role of purple sweet potato anthocyanins (PSPAs) in inducing ferroptosis in T-cell acute lymphoblastic leukemia (T-ALL).

March 2, 2026Frontiers in Bioscience-Landmark0 citationsOpen Access

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

YZYuan Zeng LLLanqin Liu JLJiayi Liu

Key Points

The research aims to investigate the role of purple sweet potato anthocyanins (PSPAs) in inducing ferroptosis in T-cell acute lymphoblastic leukemia (T-ALL).
Combined molecular docking studies
In vitro experiments using T-ALL cell lines
In vivo studies in T-ALL models
PSPAs effectively induce ferroptosis in T-ALL cells.
Modulation of the SLC7A11/GPX4 pathway was observed.
PSPAs demonstrated safety and therapeutic potential as anti-leukemia agents.

Abstract

This study provides the first evidence that PSPAs induce ferroptosis in T-ALL through modulation of the SLC7A11/GPX4 pathway. These findings reveal new mechanistic insights into ferroptosis in T-ALL and highlight PSPAs as safe, naturally derived therapeutic agents with promising therapeutic potential for leukemia.

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