ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease

Key Points

• This research aims to explore the role of ACSS2-mediated lysine crotonylation in reducing senescence and improving the effectiveness of adipose-derived stem cells in treating inflammatory bowel disease.
• Identified the epigenetic pathway involving ACSS2, Kcr, and H3K9cr.
• Analyzed the impact of Kcr modulation on the senescence of adipose-derived stem cells.
• Evaluated the therapeutic efficacy of enhanced ADSCs in inflammatory bowel disease models.
• Demonstrated that ACSS2-mediated lysine crotonylation reduces senescence in adipose-derived stem cells.
• Showed that modulation of Kcr enhances the therapeutic effects of these cells in inflammatory bowel disease.