Bioorthogonal catalytic centres engineered for gastrointestinal stabilization provide oral delivery for the treatment of gastric cancer

Key Points

• To evaluate the effectiveness of engineered exoshells for oral delivery in treating gastric cancer.
• Conducted in vitro tests to assess efficacy of exoshells.
• Performed in vivo experiments to evaluate the therapeutic potential in gastric cancer models.
• Analyzed the stability and titratability of the exoshells as a treatment platform.
• Exoshells showed significant potential for oral administration.
• Demonstrated a titratable therapeutic effect against gastrointestinal cancers.
• Results indicated improved management of gastric cancer in experimental models.