LDLR and APOB pathogenic variants predict discordant TSH effect on LDL-C

Key Points

• LDL-C levels were positively associated with TSH exclusively in patients with LDLR variants, suggesting genetic influences.
• This study highlights that TSH may not have the same effect on LDL-C levels in APOB carriers as it does in LDLR variants.
• Through observing familial hypercholesterolemia cases, the research shows a connection between genetic background and hormonal sensitivity.
• Attention to thyroid hormone levels may enhance understanding of cholesterol management in LDLR-FH patients.