Identification and characterization of trametinib degradation product employing Orbitrap LC-HRMS, and development of a robust, eco-friendly stability indicating method of analysis

Key Points

• Identification of trametinib degradation products reveals critical stability information.
• An eco-friendly stability indicating method enhances reliability in analytical testing.
• Employing orbitrap LC-HRMS provides high-resolution mass spectrometry data crucial for characterization.
• Developing a robust method supports future pharmaceutical stability studies and regulatory compliance.