Phage endolysin–polyphosphate/alginate nanocomplexes inhibit staphylococcal biofilms for implant protection

Key Points

• Endolysin-polyphosphate/alginate nanocomplexes significantly inhibit staphylococcal biofilms, enhancing implant protection.
• In vitro assays show up to 90% reduction in biofilm viability in the presence of crafted nanocomplexes.
• Investigation using a novel formulation of endolysin blended with alginate and polyphosphate to target biofilm prevention.
• These findings highlight a promising approach to combat infections related to medical implants.