General anesthesia with propofol significantly affects the number and frequency of epileptic discharges, particularly by reducing spikes while increasing HFOs. Notably, HFOs-particularly in the frontal and cingulate cortices-emerged as reliable biomarkers for delineating the SOZ and guiding surgical resections. Furthermore, no significant age-related variability was identified, supporting the applicability of intra-operative electroencephalography in pediatric epilepsy surgery.
Liu et al. (Thu,) studied this question.
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