Carboxymethyl Ethyl Cellulose-based Solid Dispersions: a Promising Approach to Enhance the Dissolution and Oral Bioavailability of Itraconazole

Key Points

• Itraconazole shows increased oral bioavailability with carboxymethyl ethyl cellulose solid dispersions, enhancing therapeutic effects.
• Bioavailability improvements were demonstrated, achieving a notable increase in dissolution rates in laboratory conditions.
• Assessment involved developing solid dispersions of itraconazole using carboxymethyl ethyl cellulose, measuring their effectiveness in improving drug delivery.
• Greater dissolution and bioavailability highlight the potential for more effective pharmaceuticals, underscoring the promise of this method.