Carboxymethyl Ethyl Cellulose-based Solid Dispersions: a Promising Approach to Enhance the Dissolution and Oral Bioavailability of Itraconazole

Madhur Kulkarni; Vaishali Shirsat; Pratiksha More; Shreya Mohite; Ayush Jaiswal

doi:10.1007/s12247-026-10388-2

January 27, 2026Journal of Pharmaceutical Innovation

Carboxymethyl Ethyl Cellulose-based Solid Dispersions: a Promising Approach to Enhance the Dissolution and Oral Bioavailability of Itraconazole

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Key Points

Itraconazole shows increased oral bioavailability with carboxymethyl ethyl cellulose solid dispersions, enhancing therapeutic effects.
Bioavailability improvements were demonstrated, achieving a notable increase in dissolution rates in laboratory conditions.
Assessment involved developing solid dispersions of itraconazole using carboxymethyl ethyl cellulose, measuring their effectiveness in improving drug delivery.
Greater dissolution and bioavailability highlight the potential for more effective pharmaceuticals, underscoring the promise of this method.

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Implication

Experimental analysis shows improved dissolution and bioavailability of itraconazole with solid dispersions, indicating a potential treatment advancement.

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Kulkarni et al. (2026) studied this question.

synapsesocial.com/papers/69a75a62c6e9836116a20204 https://doi.org/10.1007/s12247-026-10388-2

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Carboxymethyl Ethyl Cellulose-based Solid Dispersions: a Promising Approach to Enhance the Dissolution and Oral Bioavailability of Itraconazole

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Carboxymethyl Ethyl Cellulose-based Solid Dispersions: a Promising Approach to Enhance the Dissolution and Oral Bioavailability of Itraconazole

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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