Systemic inflammatory and thyroid markers for predicting malignancy in indeterminate (Bethesda III–IV) thyroid nodules; could thyroglobulin be a clue?

Key Points

• Malignancy prediction is enhanced with increased thyroglobulin levels in thyroid nodules.
• In a cohort of indeterminate thyroid nodules, thyroglobulin was notably associated with cancer risk.
• Analysis of Bethesda III–IV thyroid nodules shows the significance of thyroid and inflammatory markers.
• This approach highlights the need for further investigation into thyroglobulin's potential diagnostic role.