Tanshinone IIA&Icaritin -MPs regulated vascular normalization and restored tumor-infiltrating T lymphocyte function to boost anti-PD-1 therapy in melanoma lung metastasis | Synapse
March 3, 2026Open Access
Tanshinone IIA&Icaritin -MPs regulated vascular normalization and restored tumor-infiltrating T lymphocyte function to boost anti-PD-1 therapy in melanoma lung metastasis
Key Points
Vascular normalization correlates with enhanced tumor-infiltrating T lymphocyte function in melanoma.
Key evidence shows that the combination of tanshinone IIA and icaritin improved T lymphocyte activity and tumor response.
Assessment using vascular and immune profiling indicates how these agents interact with the tumor microenvironment.
These findings may enable better therapeutic strategies against melanoma, highlighting the potential for combined treatments.