Distinct viral strategies of Porcine Epidemic Diarrhea Virus NSP1 and NSP2 converge on KEAP1 to degrade NRF2 and suppress host antioxidant defense

Key Points

• Porcine epidemic diarrhea virus effectively degrades nrf2 to disrupt host antioxidant defenses, posing a threat to cellular integrity.
• The viral proteins nsp1 and nsp2 converge on keap1, influencing nrf2 degradation; targeting both strategies shows significant impacts.
• Analysis of viral mechanisms reveals that the intersection of nsp1 and nsp2 allows for enhanced suppression of host defenses against oxidative stress.
• These findings highlight the need for further research on viral tactics, which could inform future therapeutic interventions against such viruses.