March 3, 2026Frontiers in Microbiology0 citationsOpen Access

Multifaceted antimicrobial mechanisms of NCR147-derived peptides from Medicago truncatula

HTHilda Tiricz RLRui M. Lima IPIlona Pfeiffer

Key Points

These peptides display antimicrobial properties through a multihit mechanism, enhancing their effectiveness.
The therapeutic promise of NCR147-derived peptides stems from their potential to minimize resistance development while treating infections.
Assessment reveals the capability of these plant-derived antimicrobial peptides in fighting bacterial cells effectively.
Such advances highlight the need for further exploration of plant-based antimicrobials in modern medicine.

Abstract

These findings reveal that NCR147-derived peptides function via a multihit mechanism and highlight the therapeutic promise of plant-derived AMPs as next-generation antimicrobials with reduced risk of resistance development.

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Tiricz et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75ab8c6e9836116a20e48 https://doi.org/https://doi.org/10.3389/fmicb.2025.1720738

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