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March 3, 2026Translational Gastroenterology and Hepatology0 citationsOpen Access

Primary sclerosing cholangitis in children: a single-center experience and evaluation of prognostic markers

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EVEva VlckovaOHOndrej HradskyVSValerij Semjonov

Key Points

  • Long-term prognosis in children with primary sclerosing cholangitis is generally favorable, indicating resilience.
  • No reliable clinical factors or laboratory markers, including GGT normalization, effectively predict disease severity.
  • Evaluation includes assessing common variables: sex, age at diagnosis, and associated conditions like IBD.
  • Absence of predictive markers emphasizes the need for ongoing monitoring in pediatric cases.

Abstract

Neither the SCOPE index at diagnosis nor GGT normalization within 1 year predicted severe liver disease course. No clinical factors (sex, age at diagnosis, presence of IBD, features of AIH, or PSC subtype) or laboratory markers were found to reliably predict a severe disease course. Overall, the long-term prognosis in this pediatric cohort was generally favorable.

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Cite This Study

Vlckova et al. (2026) studied this question.

synapsesocial.com/papers/69a75ac8c6e9836116a210d3https://doi.org/10.21037/tgh-25-57
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