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March 3, 2026British Journal of Clinical Pharmacology0 citationsOpen Access

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

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DADanilo Alves‐BezerraUniversidade UnigranrioLNLuiza B. NegreirosUniversidade UnigranrioAPAmaury Pereira‐AcácioUniversidade Unigranrio

Key Points

  • Valproic acid shows potential benefits in acute kidney injury outcomes, possibly preventing chronic kidney disease.
  • Improvement metrics involve its pharmacological properties and adjuvant role in treatment.
  • Analysis presented assessment using clinical outcomes related to acute kidney injury in diverse populations.
  • This insight highlights the need for further exploration into novel uses for existing medications, which could enhance kidney health.

Abstract

Valproate has pharmacological properties that point to its potential repositioning as an adjuvant in improving several outcomes in AKI and potentially avoiding progression to chronic kidney disease.

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Cite This Study

Alves‐Bezerra et al. (2026) studied this question.

synapsesocial.com/papers/69a75ae1c6e9836116a2149fhttps://doi.org/10.1002/bcp.70456
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