Donepezil enhances the testicular protective effect of metformin in diabetic rats by modulating steroidogenic signaling and Bax/Bcl-2/Caspase-3 pathway

Key Points

• Donepezil significantly enhances the protective effect on testicular function in diabetic rats.
• The key finding shows modulation of the bax/bcl-2/caspase-3 pathway alongside steroidogenic signaling.
• Observational analysis investigated the effects of donepezil and metformin on diabetic rat models.
• This work suggests a potential new therapy for diabetes-related testicular damage, requiring further studies.