Metabolite analysis of Aspergillus fumigatus conidial supernatant and its pro-inflammatory activity in vitro and in vivo

Key Points

• The conidial supernatant induces a significant inflammatory response in macrophages, highlighting its biological impact.
• Inflammatory markers increased notably, underscoring the role of the jak/stat/mapk pathways in the response.
• Assessment utilized in vitro and in vivo methods, showing clear differences in metabolites during pre- and post-germination stages.
• Long-term exposure in mice linked to pneumonia and tissue damage, indicating possible serious health implications.