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March 3, 2026Frontiers in Endocrinology3 citationsOpen Access

The predictive potential of surrogate indicators of insulin resistance for type 2 diabetic kidney disease

QTQiuhui TianYLYu LiuQCQiumei Cao

Key Points

  • Diabetic kidney disease risk increases with higher levels of insulin resistance indicators such as TyG and TyG-BMI.
  • TyG, TyG-BMI, and TG/HDL-C exhibit strong positive correlations with kidney disease risk in diabetes.

Structured PICO

Do surrogate indicators of insulin resistance (TyG, TyG-BMI, and TG/HDL-C) predict the risk of diabetic kidney disease in patients with type 2 diabetes mellitus?

P
Population
Patients with type 2 diabetes mellitus (T2DM)
I
Intervention
Surrogate indicators of insulin resistance (TyG, TyG-BMI, and TG/HDL-C)
O
Outcome
Diabetic kidney disease (DKD) risksurrogate

TyG, TyG-BMI, and TG/HDL-C are accessible and cost-effective indicators that can predict the risk of diabetic kidney disease in patients with type 2 diabetes.

Abstract

TyG, TyG-BMI, and TG/HDL-C are positively correlated with DKD risk in T2DM patients and demonstrate substantial predictive value, supporting their potential as accessible, cost-effective indicators for DKD risk assessment.

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Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/69a75b46c6e9836116a2257ehttps://doi.org/10.3389/fendo.2026.1705701
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