SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditory cells

Key Points

• Enhanced mitophagy occurs in auditory cells following SIRT1 activation, promoting cell health and function.
• SRT2104 treatment significantly reduces cellular senescence, improving longevity and function in these cells.
• Assessment using SIRT1 activation methods showcases its role in promoting mitophagy and reducing senescence.
• Highlights the potential for SRT2104-based therapies in combating age-related hearing impairments.