Diosmin Alleviates Pain via Mechanisms Involving Acetylcholinesterase and TRPV1 Inhibition: An In Silico and In Vivo Study

Key Points

• Diosmin's antinociceptive effects are linked to acetylcholinesterase and TRPV1 inhibition, indicating pain relief mechanisms.
• The analysis highlights diosmin's role in regulating central and peripheral pain pathways, beneficial for managing pain.
• Utilizing both in silico and in vivo methods, the study outlines how diosmin interacts with cholinergic pathways and receptors.
• These findings may enable better pain management strategies and warrant further exploration of diosmin as a treatment option.