Neurobiological, molecular, and systemic mechanisms of exercise in the treatment of mental health disorders

Key Points

• Exercise significantly improves mental health outcomes, particularly through neurobiological pathways and molecular changes.
• Reported improvements in mental health were associated with enhanced neuroplasticity and reduced symptoms of depression and anxiety.
• Analysis of neurobiological, molecular, and systemic interactions highlights pathways through which exercise exerts its benefits.
• This work underlines the need for more interventions targeting molecular mechanisms linked to mental health disorders.