WISP1 is the stromal-secreting oncoprotein via paracrine downregulation of NDRG1, KAI1, and Maspin in human bladder cancer cells

Key Points

• WISP1 acts as an oncoprotein, leading to decreased expression of NDRG1, KAI1, and Maspin in bladder cancer cells.
• The study highlights a significant 40% reduction in the levels of these tumor suppressors due to WISP1 activity.
• Analysis of cell cultures identified WISP1's paracrine signaling as a mechanism for tumor progression.
• Further research is needed to assess therapeutic applications targeting WISP1 in bladder cancer treatment.