Proton pump inhibitors accelerate vascular calcification via COX-2-mediated mitophagy inhibition in chronic kidney disease

Key Points

• Vascular calcification accelerates in chronic kidney disease due to proton pump inhibitors.
• Inhibition of COX-2 leads to impaired mitophagy, contributing to this process.
• Analysis across various models indicates a consistent association between medications and calcification levels.
• Findings suggest a potential mechanistic link that could inform treatment strategies.