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Acupuncture alleviates inflammatory pain by regulating microglial polarization through α7nAchR-mediated autophagy | Synapse
March 3, 2026
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Acupuncture alleviates inflammatory pain by regulating microglial polarization through α7nAchR-mediated autophagy
GD
Guoqi Dong
Shanghai University of Traditional Chinese Medicine
HG
Hui Gao
Jiangnan University
YS
Yijun Sun
Shanghai Sixth People's Hospital
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Key Points
Inflammatory pain reduction is significantly associated with microglial polarization alterations after treatment.
Analysis indicates that acupuncture regulates α7nAChR-mediated autophagy pathways in the brain.
The study employed a systematic approach involving animal models to investigate the therapeutic effects of acupuncture.
These findings highlight the potential for acupuncture as a novel treatment to manage neuroinflammatory conditions.
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Dong et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75c05c6e9836116a245c4
https://doi.org/https://doi.org/10.1016/j.joim.2026.01.006