Kinetic and biocatalytic evaluation of dodecyl nicotinate hydrolysis in aqueous buffers and biological media

Key Points

• The hydrolysis of dodecyl nicotinate shows efficient bioconversion in biological media, indicating its potential effectiveness.
• Kinetic analysis reveals that this prodrug maintains chemical stability while facilitating tissue-mediated conversion.
• Assessment involves examining hydrolysis rates in both aqueous buffers and biological settings to ensure accurate results.
• Highlights the promising use of dodecyl nicotinate for controlled-release applications in niacin delivery.