Kinetic and biocatalytic evaluation of dodecyl nicotinate hydrolysis in aqueous buffers and biological media | Synapse
March 3, 2026
Kinetic and biocatalytic evaluation of dodecyl nicotinate hydrolysis in aqueous buffers and biological media
Key Points
The hydrolysis of dodecyl nicotinate shows efficient bioconversion in biological media, indicating its potential effectiveness.
Kinetic analysis reveals that this prodrug maintains chemical stability while facilitating tissue-mediated conversion.
Assessment involves examining hydrolysis rates in both aqueous buffers and biological settings to ensure accurate results.
Highlights the promising use of dodecyl nicotinate for controlled-release applications in niacin delivery.
Abstract
Dodecyl nicotinate combines chemical stability with efficient tissue-mediated bioconversion, supporting its promise as a controlled-release niacin prodrug suitable for both oral and transdermal delivery.