Investigation of Acoramidis-based ionic liquids as potential stabilizers of transthyretin using DFT calculations, molecular docking, and ADMET studies

Key Points

• Acoramidis-based ionic liquids stabilize transthyretin, potentially aiding treatment of amyloidosis.
• Using molecular docking, the study found binding affinities suggesting effective stabilization mechanisms.
• Assessment included density functional theory calculations and evaluations of drug-like properties through ADMET studies.
• Findings highlight the therapeutic promise of acoramidis formulations for managing transthyretin-associated diseases.