Design, synthesis, and evaluation of artesunate-benzofuran hybrids as dual anticancer and anti-inflammatory candidates: In silico profiling and in vitro validation in Caco-2, HepG2, Ishikawa, and RAW 264.7 cell lines

Key Points

• Dual anticancer and anti-inflammatory activity was observed across multiple cell lines, indicating potent therapeutic effects.
• Key evidence shows significant inhibition of cancer cell proliferation and inflammation in tested lines like Caco-2 and HepG2.
• In silico profiling guided the design, synthesis, and evaluation of artesunate-benzofuran hybrids for efficacy.
• These findings highlight the potential of such hybrids, paving the way for future research into their clinical application.