Preinjury antidepressant use, regardless of antidepressant type or serotonergic profile, was not associated with increased mortality, increased need for ANOs, or prolonged hospitalization in TBI patients. No interaction was found between VKA use and antidepressant use, serotonergic class, or type of antidepressant, suggesting that antidepressants do not exacerbate the adverse impact of VKA on these outcomes. Overall, our results suggest that preinjury antidepressant use does not worsen early clinical outcomes after TBI.
Posti et al. (Wed,) studied this question.