Overcoming size barriers in retinal gene therapy via lipid nanoparticle-mediated delivery of full-length eys DNA

Key Points

• Full-length eys DNA was effectively delivered using lipid nanoparticles, addressing size barriers.
• The method demonstrated a significant increase in gene expression compared to traditional delivery methods.
• Observational analysis focused on lipid nanoparticle-mediated delivery within retinal cells.
• These findings highlight an effective strategy for overcoming delivery challenges in retinal gene therapy.