Metabolic and antioxidant imbalance in Sertoli cells induced by tributyltin exposure is accompanied by Sirt3 downregulation

Key Points

• Sertoli cells experience significant metabolic and antioxidant imbalance following tributyltin exposure, impacting cellular function.
• The critical enzyme Sirt3 is notably downregulated, highlighting a specific pathway affected by toxic exposure.
• The analysis uses cellular assays to assess oxidative stress and metabolic changes in response to tributyltin.
• These findings indicate that tributyltin exposure disrupts normal cellular metabolism and antioxidant defense mechanisms.