Codon usage optimization contributes to evolutionary dynamics of TetM following its acquisition via interspecies and intergeneric recombination events in recipient bacteria

Key Points

• Codon usage optimization contributes significantly to the evolutionary dynamics of TetM, enhancing bacterial adaptability.
• Notably, interspecies and intergeneric recombination events play a critical role in the acquisition of TetM among bacteria.
• Study involved an assessment of how these recombination events influence the genetic landscape of recipient bacteria.
• Implications highlight the importance of codon usage as a factor in antibiotic resistance evolution, necessitating further exploration.