T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Key Points

• Hyperreactive B-T cell interactions contribute to disease activity in multiple sclerosis.
• Key evidence includes elevated T-bet+ CXCR3+ B cells in the immune response context.
• Analysis of immune interactions in multiple sclerosis highlights the role of cytokines.
• Findings indicate clinical implications for targeting B-T cell interactions in therapy.