SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies

Key Points

• SanHuang decoction promotes M1 macrophage polarization, leading to increased cytokine expression and inflammatory response.
• Findings indicate enhanced tumor microenvironment activity resulted in reduced breast cancer cell proliferation.
• Observational analysis involved both in vitro and in vivo studies to assess the regulation of macrophage polarization.
• Supporting evidence may enable new therapeutic strategies to target breast cancer progression with inflammation-related interventions.