Rational design of 2-substituted thio-7-chloroquinazolin-4(3H)-one derivatives as dual EGFR/VEGFR-2 inhibitors with broad-Spectrum anticancer and apoptotic activities | Synapse
March 3, 2026
Rational design of 2-substituted thio-7-chloroquinazolin-4(3H)-one derivatives as dual EGFR/VEGFR-2 inhibitors with broad-Spectrum anticancer and apoptotic activities
Key Points
Dual inhibitors showed significant anticancer and apoptotic activities, targeting EGFR and VEGFR-2.
The novel thio-7-chloroquinazolin-4(3H)-one derivatives were synthesized and tested for efficacy.
Evaluations involved assessing cell viability and apoptosis in various cancer cell lines under specific conditions.
The findings support the potential of these compounds in developing new cancer therapies.