A venom fraction from the Philippine tarantula (Orphnaecus sp.) reveals low-molecular-weight compounds that potentiate drug-like neurobehavioral responses in Danio rerio

Key Points

• Venom fractions induce pronounced neurobehavioral effects, including hyperactivity and anxiolytic-like responses.
• Key findings suggest potential antinociceptive properties linked to low-molecular-weight compounds in the venom.
• Assessment of venom effects was conducted using Danio rerio, a model widely used in neurobehavioral studies.
• These findings highlight therapeutic possibilities for drug development based on tarantula venom components.