Subchronic exposure to tri-ortho-cresyl phosphate induces nephrotoxicity through induction of oxidative stress with neuropathy target esterase inhibition

Key Points

• Nephrotoxicity is induced by tri-orto-cresyl phosphate exposure, exacerbated by oxidative stress.
• The observed oxidative stress was linked to the inhibition of neuropathy target esterase in animal models.
• Analysis of cellular responses highlighted significant biomarkers related to kidney function impairment.
• This raises concerns about environmental exposure and the potential health impacts on humans.