Altered gene expression associated with Alzheimer's disease in the SH-SY5Y neuroblastoma cell model: Enhanced intracellular GSK3β and Cyclophilin A, as key neuropathology-inducing factors | Synapse
March 3, 2026
Altered gene expression associated with Alzheimer's disease in the SH-SY5Y neuroblastoma cell model: Enhanced intracellular GSK3β and Cyclophilin A, as key neuropathology-inducing factors
Key Points
Enhanced levels of gsk3β and cyclophilin a correlate with Alzheimer's neuropathology.
The study highlights significant changes in gene expression in a neuroblastoma cell model relevant to Alzheimer's.
This analysis utilizes SH-SY5Y cells to investigate the effects of specific proteins on neurodegenerative pathways.
Findings indicate that gsk3β and cyclophilin a may play critical roles in cellular mechanisms associated with Alzheimer's.