Single-cell immune atlas of mouse testes unveils metabolic reprogramming of FOLR2 + macrophages in orchestrating testicular immunity during aging

Key Points

• Macrophages show significant metabolic reprogramming during aging, influencing testicular immunity.
• FOLR2-positive macrophages were specifically assessed to understand their role in immune responses.
• The study utilized single-cell analysis to explore cellular mechanisms in mouse testes.
• Results suggest potential targets for interventions to improve testicular immunity during aging.