March 3, 2026Journal of Ethnopharmacology1 citationsOpen Access

Ganoderic Acid A alleviates ulcerative colitis by inhibiting the interleukin17 signaling pathway via targeting retinoic acid-related orphan receptor alpha

YYYifei YeNanchang University YCYinni ChenHefei University of Technology YCYinni ChenHefei University of Technology

Key Points

Ganoderic Acid A significantly reduces inflammation in ulcerative colitis, indicating its therapeutic value.
Key measure shows decreased IL-17 pathway activation following treatment with Ganoderic Acid A.
The approach involves assessing how Ganoderic Acid A interacts with the RORA receptor to target inflammatory responses.
This study suggests that Ganoderic Acid A could be an effective nutritional intervention, requiring further investigations.

Abstract

Our findings disclose that GAA alleviated DSS-induced UC by inhibiting the IL-17 signaling pathway via targeting RORA to reduce inflammation. Our study suggests that GAA holds potential as a nutritional intervention for the prevention and treatment of UC.

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Cite This Study

Ye et al. (Fri,) studied this question.

synapsesocial.com/papers/69a75eccc6e9836116a29ba3 https://doi.org/https://doi.org/10.1016/j.jep.2026.121297

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