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March 3, 2026
Open Access
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis
JG
Jing Gong
École Polytechnique Fédérale de Lausanne
QW
Qian Wang
École Polytechnique Fédérale de Lausanne
JZ
Jieping Zhu
Chemical Synthesis Lab
Key Points
1,3-migrations were successfully achieved using a palladium catalyst, demonstrating effective regiodivergence in the reaction.
Key evidence includes a notable efficiency improvement in organizing molecular arrangements through consecutive 1,2-rearrangements.
Observational analysis showcased palladium catalysis facilitating complex organic transformations through unique migration patterns.
This approach highlights new competitive pathways in organic synthesis, which may inspire future advancements in molecular design.
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Gong et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f50c6e9836116a2a9c0
https://doi.org/https://doi.org/10.1038/s44160-025-00979-1
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis | Synapse